Beata Pyrzyńska, PhD
Research
The team carries research in the following areas:
Development of therapeutic alternatives in combination with monoclonal antibodies for cancer therapy
Characterization of tumoral, metabolic and immune cross talks, controlling malignant growth and affecting cancer therapies
Molecular mechanisms regulating endocytic and exocytic pathways in cells
In our projects we use methods of molecular biology, genetic modification of cells, variety of functional tests, flow cytometry, immunophenotyping, bioinformatics and mouse models of tumors
Principal Investigator
Dr Beata Pyrzyńska: Adjunkt at Immunoloy Department of Medical University in Warsaw
Visiting Researcher:
- Oct.-Nov. 2018: The Francis Crick Institute, London, United Kingdom, collaboration with Prof. Dinis Calado
- June-July 2018: International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, collaboration with Prof. Dimitar Efremov
- Feb.-March and Oct.-Nov. 2017: International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, collaboration with Prof. Dimitar Efremov
- August-Sept. 2016: The Francis Crick Institute, London, United Kingdom, collaboration with Prof. Dinis Calado
- June-July 2015: Inserm, U1068, Centre Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, CNRS, UMR7258, Aix-Marseille University, Marseille, France, collaboration with Dr. Cyril Fauriat
- 2002 -2006: PostDoctoral Fellow, Lab. of Prof. E.G. Van Meir, Dept. of Neuro-Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, US;
- Feb.-July 1999 and Oct. 2000: EMBO Fellowship, National Center of Biotechnology, Dept. of Immunology and Oncology, Madrid, Spain; Collaboration with Dr. M. Serrano and Prof. C. Martinez-A;
- May-Aug. 1995: Research Fellowship, Institute of General Pathology, Perugia, Italy
Memberships:
American Association for Cancer Research (AACR)
Editorships & Reviewing boards:
Cellular and Molecular Neurobiology (CEMN)
Team members
Scientific advisor & consultant: Abdessamad Zerrouqi, PhD
Postdoctoral Fellows: dr Anna Toruń
Research projects
Komórki NK z indukowalną ekspresją CAR jako nowa immunoterapia zwiększająca skuteczność przeciwciał monoklonalnych.
Narodowe Centrum Nauki, Progam OPUS, Lata realizacji: 2017-2020, Kierownik: Beata Pyrzyńska
Research papers
2019
Sasi B.K., Martines C., Xerxa E., Porro F., Kalkan H., Fazio R., Turkalj S., Bojnik E., Pyrzynska B., Stachura J., Zerrouqi A., Bobrowicz M., Winiarska M., Priebe V., Bertoni F., Mansouri L., Rosenquist R., Efremov D.G. (2019). Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma. Leukemia doi: 10.1038/s41375-019-0442-8. [Epub ahead of print] https://www.nature.com/articles/s41375-019-0442-8
2018
Pyrzynska B., Dwojak M., Zerrouqi A., Morlino G., Zapala P., Miazek N., Zagozdzon A., Bojarczuk K., Bobrowicz M., Siernicka M., Machnicki M.M., Gobessi S., Barankiewicz J., Lech-Maranda E., Efremov D.G., Juszczynski P., Calado D., Golab J., Winiarska M. (2018). FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy. Oncoimmunology 7(5):e1423183. doi:10.1080/2162402X.2017.1423183. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927521/
2017
Bobrowicz M., Dwojak M., Pyrzynska B., Stachura J., Muchowicz A., Berthel E., Dalla-Venezia N., Kozikowski M., Siernicka M., Miazek N., Zapala P., Domagala A., Bojarczuk K., Malenda A., Barankiewicz J., Graczyk-Jarzynka A., Zagozdzon A., Gabrysiak M., Diaz J.J., Karp M., Lech-Maranda E., Firczuk M., Giannopoulos K., Efremov D.G., Laurenti L., Baatout D., Frenzel L., Malinowska A., Slabicki M., Zenz T., Zerrouqi A., Golab J., Winiarska M. (2017). HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies. Blood 130(14):1628-1638. doi: 10.1182/blood-2016-08-736066. http://www.bloodjournal.org/content/130/14/1628
2016
Słabicki M., Lee K.S., Jethwa A., Sellner L., Sacco F., Walther T., Hüllein J., Dietrich S., Wu B., Lipka D.B., Oakes C.C., Mamidi S., Pyrzyńska B., Winiarska M., Oleś M., Seifert M., Plass C., Kirschfink M., Boettcher M., Gołąb J., Huber W., Fröhling S., Zenz T. (2016). Dissection of CD20 regulation in lymphoma using RNAi. Leukemia 30(12):2409-2412. doi:10.1038/leu.2016.230. https://www.nature.com/articles/leu2016230
2015
Dwojak M., Bobrowicz M., Bil J., Bojarczuk K., Pyrzynska B., Siernicka M., Malenda A., Lech-Maranda E., Tomczak W., Giannopoulos K., Golab J., Winiarska M. (2015). Sorafenib improves rituximab and ofatumumab efficacy by decreasing the expression of complement regulatory proteins. Blood Cancer J. 5:e300. doi: 10.1038/bcj.2015.27. https://www.nature.com/articles/bcj201527
Toruń A., Szymańska E., Castanon I., Wolińska-Nizioł L., Bartosik A., Jastrzębski K., Miętkowska M., González-Gaitán M., Miaczynska M. (2015). Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. PLoS One 10(6):e0130818. doi: 10.1371/journal.pone.0130818. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.01308…
2014
Zerrouqi A., Pyrzynska B., Brat D.J., Van Meir E.G. (2014). P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway Cancer Res. 74, 1371-8. doi: 10.1158/0008-5472.CAN-13-1951. http://cancerres.aacrjournals.org/content/74/5/1371.long
Bojarczuk K., Siernicka M., Dwojak M., Bobrowicz M., Pyrzynska B., Gaj P., Karp M., Giannopoulos K., Efremov D.G., Golab J., Winiarska M. (2014). B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies. Leukemia 28, 1163-7. doi: 10.1038/leu.2014.12. https://www.nature.com/articles/leu201412
Winiarska M., Bojarczuk K., Pyrzynska B., Bil J., Siernicka M., Dwojak M., Bobrowicz M., Miazek N., Zapala P., Zagozdzon A., Krol M., Syta A., Podszywalow-Bartnicka P., Pilch Z., Dabrowska-Iwanicka A., Juszczynski P., Efremov D.G., Slabicki M., Zenz T., Le Roy A., Olive D., Rygiel T.P., Leusen J., Golab J. (2014). Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies. mAbs 6, 1300-13. doi: 10.4161/mabs.32106. https://www.tandfonline.com/doi/full/10.4161/mabs.32106